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The effect of gestational diabetes mellitus on human milk macronutrients content

Journal of Perinatology volume 39, pages 820–823 (2019)Cite this article

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Abstract

Objective

To test the null hypothesis that human milk (HM) macronutrients (fat, lactose, protein) and caloric content in women with gestational diabetes mellitus (GDM) is similar to that of women without GDM.

Study design

Sixty-two lactating mothers (31 GDM, 31 no-GDM) were studied after confirmation by 100-g oral glucose tolerance test. Each mother contributed three manually expressed HM samples (within 72 h after labor (colostrum), after 7 days (transitional) and at 14 days (mature)). Analysis was done by infrared transmission spectroscopy.

Results

Non-GDM and GDM groups did not differ by maternal age, pre-pregnancy weight, height, diet, pregnancy weight gain, gestational age, and infant birth weight. Macronutrients content in colostrum and transitional milk did not differ between groups. Fat and energy contents in mature HM were higher in non-GDM samples than in GDM samples (p = 0.07 and p < 0.02, respectively).

Conclusion

Fat and energy content of mature HM obtained from mothers with GDM is lower compared to that of mature HM from mothers without GDM.

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Author information

Author notes

  1. These authors contributed equally: Dana Shapira, Dror Mandel

Authors and Affiliations

  1. Department of Pediatrics, Dana Dwek Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

    Dana Shapira, Hadar Moran-Lev & Ronit Lubetzky

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Dana Shapira, Dror Mandel, Francis B. Mimouni, Hadar Moran-Lev, Ronella Marom & Ronit Lubetzky

  3. Department of Neonatology, Dana Dwek Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

    Dror Mandel, Ronella Marom & Laurence Mangel

  4. Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel

    Francis B. Mimouni

Authors
  1. Dana Shapira
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  2. Dror Mandel
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  3. Francis B. Mimouni
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  4. Hadar Moran-Lev
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  5. Ronella Marom
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  6. Laurence Mangel
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  7. Ronit Lubetzky
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Corresponding author

Correspondence to Dror Mandel.

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Shapira, D., Mandel, D., Mimouni, F.B. et al. The effect of gestational diabetes mellitus on human milk macronutrients content. J Perinatol 39, 820–823 (2019). https://doi.org/10.1038/s41372-019-0362-5

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  • DOI: https://doi.org/10.1038/s41372-019-0362-5

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