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Congenital solitary kidney size at birth could predict reduced eGFR levels later in life

Journal of Perinatology volume 39, pages 129–134 (2019)Cite this article

Subjects

Abstract

Objectives

To evaluate the impact of congenital solitary functioning kidney (CSFK) length, measured early in life, on the eGFR levels during the follow-up.

Study design

We retrospectively selected 162 CSFK patients undergoing, within 60 days of life, renal length (RL) measurement by ultrasound.

We divided the population in:

  • Group 1 = RL ≥ 2 standard deviation score (SDS).

  • Group 2 = RL < 2 SDS and showing RL ≥ 2 SDS during the follow-up.

  • Group 3 = RL < 2 SDS and showing RL < 2 SDS during the follow-up.

Primary outcome: development of eGFR below the range of normality.

Results

The median follow-up period of the overall population was 6.2 years (range 2–21.5 years). The cumulative proportion of patients free of primary outcome at 15 years of age was 96.4% in group 1, 64.6% in group 2, and 45.6% in group 3 (p = 0.03).

The RL > 2 SDS within 60 days of life was a significant protective factor (hazard ratio = 0.13; 95% C.I. 0.02–0.97) against development of primary outcome.

Conclusion

RL ≥ 2 SDS within 60 days of life could identify a population of CSFK with reduced risk of presenting reduced eGFR levels later in life.

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Acknowledgements

The authors thank Anna Carella and Simona Malvone for reviewing the English language of this manuscript.

Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, Via Luigi De Crecchio 2, 80138, Napoli, Italy

    Pierluigi Marzuillo, Stefano Guarino, Anna Grandone, Allegra Di Somma, Mario Diplomatico, Fabio Decimo, Emanuele Miraglia del Giudice, Angela La Manna & Cesare Polito

  2. Department of Radiological Sciences, Nuclear Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, Naples, Italy

    Pier Francesco Rambaldi

Authors
  1. Pierluigi Marzuillo
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  2. Stefano Guarino
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  3. Anna Grandone
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  4. Allegra Di Somma
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  9. Angela La Manna
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  10. Cesare Polito
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Correspondence to Pierluigi Marzuillo.

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Marzuillo, P., Guarino, S., Grandone, A. et al. Congenital solitary kidney size at birth could predict reduced eGFR levels later in life. J Perinatol 39, 129–134 (2019). https://doi.org/10.1038/s41372-018-0260-2

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  • DOI: https://doi.org/10.1038/s41372-018-0260-2

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