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Outcomes of extremely premature infants with twin–twin transfusion syndrome treated by laser therapy

Journal of Perinatology volume 38, pages 1548–1555 (2018)Cite this article

Subjects

Abstract

Objective

To compare short-term and long-term outcomes of preterm infants born at <29 weeks of gestational age (GA) with twin–twin transfusion syndrome (TTTS) treated with laser therapy to preterm twin infants without TTTS.

Design

Retrospective case–control study comparing 33 preterm TTTS twins to 101 preterm diamniotic–dichorionic (di–di) twins born at our institution between 2006 and 2015.

Results

GA at birth were 26.4 ± 1.4 weeks (TTTS) and 26.9 ± 1.6 weeks (di–di) (p = 0.07). TTTS premature newborns were less exposed to antenatal steroids (p = 0.01), more frequently born by C-section (p = 0.005), received more surfactant therapy (p = 0.004, and were smaller for GA (p < 0.001). When adjusted for antenatal steroids and birth weight, TTTS status was not associated with increased mortality (HR 1.66, 95% CI 0.77–3.56, p = 0.20). No differences were found on neurodevelopmental outcomes at 18 months of corrected GA.

Conclusion

Premature TTTS newborns treated with fetal laser therapy had similar survival and neurodevelopmental outcomes compared to preterm di–di twins without TTTS.

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Author notes

  1. These authors contributed equally: Gabriel Altit, Anie Lapointe.

Authors and Affiliations

  1. Department of Pediatrics, Division of Neonatology, CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada

    Julie Sommer, Anne-Monique Nuyt, Véronique Dorval & Anie Lapointe

  2. Department of Obstretrics and Gynecology, CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada

    François Audibert & Sandrine Wavrant

  3. Department of Pediatrics, Division of Neonatology, Montreal Children’s Hospital, McGill University, Montréal, QC, Canada

    Gabriel Altit

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Correspondence to Anie Lapointe.

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Sommer, J., Nuyt, AM., Audibert, F. et al. Outcomes of extremely premature infants with twin–twin transfusion syndrome treated by laser therapy. J Perinatol 38, 1548–1555 (2018). https://doi.org/10.1038/s41372-018-0202-z

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