Abstract
Objective: Antibiotics for nontyphoid salmonellosis has long been a controversial matter. Most studies didn't claβify the salmonellosis with severity of disease. The purposes of the study were to investigate the outcomes of the mild nontyphoid salmonellosis children with antibiotics therapy.
Material and methods: This is a prospective observational study. Between 2005 and 2008, all pediatric patients with nontyphoid salmonellosis admitted to Kaohsiung Veterans General Hospital, Taiwan, were claβified with severity score. The severity score is composed of three parameters:
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1. C-reactive protein ≤ 3 mg/dL; > 3, ≤6; > 6: 0; 1; 2
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2. Band cells in blood ≤ 5%; > 5, ≤ 10; > 10: 0; 1; 2
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3. Days of fever before admiβion < 3 days; ≥3: 0; 1
Score greater than 3, 2 or 3 and ≤ 1 was considered severely, moderately and mildly ill respectively. Mildly ill salmonellosis patients treated with or without antibiotics were collected. All patients were followed until two consecutive rectal swabs were negative for Salmonella. The demographic data, clinical manifestations, laboratory data, response to treatment and duration of fecal excretion of Salmonella were recorded.
Results: Fifteen patients were enrolled into the study and six patients were in antibiotics treatment group. The demographic data, clinical manifestations and laboratory data were comparable between two groups. Significantly longer days of fever after admiβion, longer hospitalization days and longer days of fecal excretion in the antibiotics treatment group.
Conclusions: Antibiotics are not mandatory for the subset of nontyphoid salmonellosis children with low severity score.
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Huang, IF. 774 Antibiotics Therapy in Mild Nontyphoid Salmonellosis Children Prolonged Hospitalization and Fecal Excretion Time-A Preliminary Report. Pediatr Res 68 (Suppl 1), 391 (2010). https://doi.org/10.1203/00006450-201011001-00774
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DOI: https://doi.org/10.1203/00006450-201011001-00774