Abstract
Background: Near-infrared spectroscopy (NIRS) provides a continuous, non-invasive method to measure regional changes in tissue oxygenation. Spatially resolved spectroscopy as an algorithm allows the calculation of the cerebral tissue oxygenation index (TOI) which expresses the ratio between oxygenated haemoglobin and total haemoglobin in the observed tissue. Objective: Comparison of the TOI measured by NIRS and venous oxygen saturation in the jugular bulb (SjO2) during cardiac catheterization. Additionally we investigated the influence of body weight on the validity of NIRS measuring.
Methods: Patients: Fifty-three children (median age: 3.5 years, range: 0.1 to 16 years) admitted for cardiac catheterization of cyanotic and non-cyanotic congenital heart defects. Cerebral TOI was compared to SjO2 taken from the jugular bulb during cardiac catheterization. First, Pearson‘s correlation coefficients and p-values were calculated for all patients and than recalculated respectively for the Patients divided into two groups of over and under 10 kg body weight.
Results: Simultaneously measured values for SjO2 (68.5 ± 9.8 %, 40–84.1 %) and cerebral TOI (66.4 ± 7.2 %, 39–80 %) showed a significant correlation (r= 0.6, p< 0.001). Correlation in the group of children under 10 kg (N= 22) was even stronger (r= 0.8, p< 0.001) whereas correlation in children over 10 kg body weight was only significant on the level p< 0.05 (r= 0.44).
Conclusion: Cerebral tissue oxygenation measured by near- infrared spectroscopy shows a significant correlation with venous saturation of the jugular bulb. This correlation is stronger in children under 10 kg body weight which may be due to the higher transparency and convexity of the infantile skull.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fleck, T., Nagdyman, N., Schubert, S. et al. 86 Comparison Between Cerebral Tissue Oxygenation Index Measured by Near- Infrared Spectroscopy and Venous Jugular Bulb Saturation in Children. Pediatr Res 56, 478 (2004). https://doi.org/10.1203/00006450-200409000-00109
Issue Date:
DOI: https://doi.org/10.1203/00006450-200409000-00109