Abstract 639
Introduction: Previous reports have suggested an etiological association between H. pylori infection and SIDS ( Gastroenterology 1997).
Aims: To critically examine this association by different techniques i.e.: histology, immunohistochemistry, and PCR.
Methods: Paraffin embedded tracheal and stomach specimens of 25 infants, 6 months of age or younger, who dies from SIDS in WV between 1995-97 were examined. All specimen were evaluated by Histology (H&E, Giemsa), Immunohistochemistry (242M; BioGenex), and nested-PCR.
Results: Twenty three of 25 specimen were adequate for histological examination. Mild chronic gastritis was found in 3 (13%) specimens. H. pylori organism was not identified by Giemsa stain in any of the trachea or stomach specimens. Immunohistochemistry was negative for H. pylori organisms in all specimens. In 6 different specimens (stomach-3, trachea-3), H. pylori DNA was identified by nested-PCR. In none was H. pylori DNA detected in both stomach and trachea.
Conclusion: (1) The presence of H. pylori organism in both trachea and stomach from infants with SIDS was not confirmed. (2) H. pylori failed to show an etiological role in this syndrome.
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Elitsur, Y., Triest, W., Sabet, Z. et al. Sudden Infant Death Syndrome (SIDS) and Helicobacter Pylori Infection in Children. Pediatr Res 45, 110 (1999). https://doi.org/10.1203/00006450-199904020-00656
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DOI: https://doi.org/10.1203/00006450-199904020-00656