Adolescent with hirsutism due to ovarian hyperandrogenism have been described as a group characterized by insulin resistance. It is theorized that hyperinsulinemia acting on their own as well as synergistically with LH and IGF1 causes ovarian hyperstimulation and consequent over secretion of androgens which results in hirsutism. The aim of this study was to determine the relationship between insulin, androgen and growth factors in 16 adolescent girls CA: 15,24 ± 1,16 (X ± SD), BMI: 27,59 ± 5,62 (X± SD), hirsutism score: 10,73 ± 3,32 (X ± SD Ferriman and Gallway) and menstrual disorders: oligomenorrhea, n=12, amenorrhea, n=2, eumenorrhea, n=2. Deficiency of 21 hydroxylase and other diseases were excluded. After blood samples were obtained for measurement of IGF1, insulin, IGFBP1, IGFBP3, a oral glucose tolerance test was performed in the early follicular phase. We found that insulin correlated with the BMI (r: 0,63 p<0,01) and with testosterone (r:0,55 p<0,033). Not correlation was found between insulin and IGF1 or IGFBP3. In a preliminary study free IGF1(FIGF1-IRMA) was measured in 9 of the patients. A highly positive correlation was found between insulin and FIGF1 (r: 0,90 p<0,0001) and FIGF1-I/GLU ratio (r:0,87 p<0,005). This results suggest that hyperinsulinemia may play a role in increasing IGF1 bioavailability which enhance androgen production. Futher studies are needed to confirm this findings.