Objective: to determine the perinatal risk factors of neurodevelopmental disabilities of very preterm birth applying logistic regression analysis.
Design: prospective, geographically-defined collaborative study in the region of Franche-Comtè(France).
Subjects: perinatal and follow-up data were collected on 203 consecutive liveborn singleton or twin non malformed infants with gestational age less than 33 weeks from 10/01/90 to 09/30/92.
Main outcome measure: rate of cerebral palsy and severe mental retardation determined by family-physician or pediatrician with a screening-skill test performed at two years of age.
Results: 167/171 (98%) survivors were evaluated. Twenty-two of the 167 examined infants (13.2%) showed signs of cerebral palsy, 10 of these showed a severe cerebral palsy or mental retardation. Risk factors of disabilities are in a multivariate approach: premature rupture of membranes>=48h (OR: 4.3, 95% confidence interval 1.6-11.8), monochorionic-twin placentation (OR: 6.0, 95% CI 1.7-21.3), respiratory distress syndrome (OR: 2.8, 95% CI 1.1-7.1).
Conclusion: this geographically-defined prospective study gives epidemiological data and strongly suggests that a link does exist between prenatal events (monochorionic-twin placentation, premature rupture of membranes), post-natal event (respiratory distress syndrome) and neurological disabilities of ancient preterm infants.
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Antoine, B., Elisabeth, M., Jean-Yves, P. et al. Some Risk Factors for Cerebral Palsy in Extremely Premature Infants : Importance of Premature Rupture of Membranes and Monochorionic-Twin Placentation 1199. Pediatr Res 43 (Suppl 4), 206 (1998). https://doi.org/10.1203/00006450-199804001-01220
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DOI: https://doi.org/10.1203/00006450-199804001-01220