72 children 18 mo to 4 yrs of age were enrolled in year 1 of a 2-yr study of response to pneumo- coccal conjugate and polysaccharide vaccines. 34 otitis-free children (mean episodes/ past yr=.3) from a private pediatric office, and 38 otitis-prone children (5.2 episodes/past yr) from children scheduled to have tympanostomy tubes were randomized to receive pneumococcal polysaccharide vaccine (Pnu-immune, Lederle) or an investigational heptavalent pneumococcal conjugate vaccine (Lederle-Praxis). Pre- and post- immunization sera were obtained for measurement of antibody to pneumococcal serotypes 6, 14, 19 and 23. Antibody levels (mcg/ml) were measured by ELISA.Table
Children in both groups responded well to conjugate vaccine. Otitis-prone children responded better to conjugate than to polysaccharide vaccine. Funded by a grant from Lederle-Praxis.
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Barnett, E., Pelton, S., Eavey, R. et al. Response to pneumococcal conjugate and polysaccharide vaccines in otitis-prone and otitis-free children. • 686. Pediatr Res 41 (Suppl 4), 117 (1997). https://doi.org/10.1203/00006450-199704001-00706
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DOI: https://doi.org/10.1203/00006450-199704001-00706