Cerebral Haemodynamic Effects of Indomethacin and Ibuprofen During Treatment for Patent Ductus Arteriosus (Pda). 27

Background: Indomethacin (IND) reduces cerebral perfusion in preterm infants. We performed a randomised double blind study to determine if Ibuprofen (IBU) has similar effects. Subjects and Interventions: 33 infants of 23-36 wks (median 26) gestation were treated with IBU 10 mg.kg^-1 then 5 mg.kg^-1 twice 24 hourly or IND 0.10-0.25 mg.kg^-1 thrice 12 hourly injected over 15 min. The effects on cerebral blood flow (CBF), volume (CBV) and response to changes in PaCO₂ (CBVR) were observed by near infrared spectroscopy, and ductal patency assessed by echocardiograpy.Table

Table 1

Data given: mean (SD) or median (25-75 centiles) for first doses.^*=p<0.05. PDA closed in 12/14 infants with IND and 15/19 with IBU. Conclusion: IBU causes no reduction in CBF, CBV and CBVR and appears to mediate PDA closure.