Bolus SF dosing is effective, widely used but difficult to standarise and may cause acute adverts events.
Aim. To prove if simplified SF dosing might decrease incidence of hypoxia and bradycardia (drop SatO2 20%, HR<80bpm), without affecting its efficacy in RDS.
Subjects and intervention. Infants (IPPB, FiO2≥0,4) randomly received CurosurfR (200 mg/Kg) by bolus (n=78) or simplified method (N=78): full dose given in 60-s by side tube of a special tracheal tube. Baby's position was not changed and IPPB not interrupted.
Results. At entry, birth weight (1307±375g; 1319±380g), gestation (29±3; 30±2wks), prenatal steroids, Apgar scores, gender, IPPB settings and blood gases were similar in both groups. Fewer episodes of hypoxia were seen in side-tube group (44.4 vs 21.3%;p<0.01). Number of SF doses, incidence of air leaks, IVH, ductus, BPD and survival without (85 vs 82%) were also similar.
Conclusion. A simplified method (no fractioning and IPPB interruption) was as effective as classical bolus SF delivery and decrease bradycardia episodes.
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(*) Krauel X. Altirribe O. Natal A, Moral A (Barcelona); Morcillo J(Valencia); Closs R (Tarragona); Molina G (Vitoria); Arregui A(Leganés); Simonet J (Mallorca); Pedraz C (Salamanca); Sartana MS(Girona); Pantoja A (Toledo); Aburto F (Huelva); Carretero V (Cáceres), Sastre E (Burgos), Marco Tello A (Zaragoza); Orgado MJ (Cuenca).
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Valls-I-Soler, A., Fernández-Ruanova, B., López-Heredia, J. et al. A Prospective Trial of A Side-Tube Surfactant (Sf) Dosing. 237. Pediatr Res 40, 554 (1996). https://doi.org/10.1203/00006450-199609000-00260
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DOI: https://doi.org/10.1203/00006450-199609000-00260
