The purpose of this study was to evaluate motor, cognitive, and sensory outcomes of infants < 29 weeks gestation enrolled in a randomized double-masked comparison trial of two surfactants (EXO vs INFA) for the prevention of RDS. 236 infants (63%) at 4 centers received the Bayley scales and an expanded neurological examination at age 2 years. Assessors were masked to neonatal treatment status. Table
Overall at age 2 years, 84% EXO and 83% INFA were free of any cerebral palsy, 37% of EXO and 31% of INFA had major cognitive impairment (MDI <70). 37% of EXO and 45% of INFA were at risk (MDI 70-89) for future disabilities.
We conclude that ND outcome at 2 years is not influenced by the choice of either EXO or INFA for RDS prophylaxis. Funded by ONY, Inc., and Forest Laboratories.
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Zorn, W., Msall, M., Rogers, B. et al. TWO YEAR NEURODEVELOPMENTAL OUTCOME OF INFANTS <29 WEEKS ENROLLED IN A MULTICENTER COMPARISON TRIAL OF EXOSURF (EXO) AND INFASURF (INFA) PROPHYLAXIS FOR RDS. † 1696. Pediatr Res 39 (Suppl 4), 285 (1996). https://doi.org/10.1203/00006450-199604001-01720
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DOI: https://doi.org/10.1203/00006450-199604001-01720
