THE HEMODYNAMIC RESPONSE TO HIGH FREQUENCY PARTIAL LIQUID VENTILATION IN THE PRETERM LAMB WITH RESPIRATORY DISTRESS SYNDROME (RDS). † 1469

Partial liquid ventilation with perflubron (LiquiVent^®) has been shown to improve lung mechanics and gas exchange in infants with severe RDS. We studied the pulmonary and systemic hemodynamic response to high frequency partial liquid ventilation (hfPLV; Sensormedics 3100A) as compared with high frequency gas ventilation (hfGV) over 5 hours in the preterm lamb model of severe RDS (gest age 125-128 d). Lambs were ventilated with mean airway pressure 15 cmH₂O, 8-10 Hz, amplitude 22 - 50 cmH₂O adjusted for P_a CO₂, and F_IO₂ 1.0. With hfPLV, pulmonary artery pressure (P_PA) was consistently less than systemic artery pressure (P_AO) with mean P_AO-P_PA 8.2 to 2 9mmHg; in the hfGV group, P_PA was simlar to P_AO (mean P_AO - P_PA -1.2 to -2.2 mmHg). Mean CVP for both groups ranged from 2 to 4 cmH₂O. Left pulmonary artery flow(Q_PA) increased, left pulmonary vascular resistance (PVR) decreased, and P_AO stabilized with hfPLV (†P<0.05). We conclude that hfPLV improves and stabilizes pulmonary and systemic hemodynamics when compared to hfGV in the preterm lamb with severe RDS. Funded in part by Alliance Pharmaceutical Corp, Sensormedics Corp.Table

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