Objective: FTT is common in human immunodeficiency virus-infected(HIV) children. We sought to determine the effect of enteral nutritional intervention on height, weight, growth velocity, immune status, and morbidity in this multifactorial process. Methods: A retrospective analysis of 9 HIV-infected children with Acquired Immunodeficiency Syndrome (AIDS), age 8 months to 10 years, who had received greater than 6 months (mos.) of supplemental nutrition. Outcome measures included height, weight, growth velocity, CD4+ T-lymphocyte count. Compliance and measurements were determined approximately every 2-3 mos. beginning 1 year prior to intervention and continuing for a minimum of 12 mos. after. Results: On average, the interval between FTT diagnosis and NG placement or GT placement was 15 and 17 mos. respectively. All children received nutritional supplementation (65-85% of caloric needs) for a minimum of 6 mos. Weight increased (0.62 kg versus(vs.) 1.32 kg) in the 6 mos. prior to vs. 6 mos. following intervention, respectively. Growth velocity was unchanged at 4.14 cm vs. 3.86 cm. CD4+ and CD8+ lymphocyte percentages were unchanged while the absolute neutrophil counts (ANC) rose. Number (2.3 vs. 1.8 stays) but not duration (6.8 vs. 11.0 days/stay) of hospital stays were decreased as compared to preintervention periods. There were no complications from tube placement or the regimens used.Conclusion: Enteral nutritional interventions resulted in improved weight gain. Immune status was unchanged though an increased ANC was noted. Morbidity may also be decreased as the number of hospital stays was decreased following nutritional intervention. However, a significant delay between diagnosis and intervention was noted. Therefore, enteral nutritional intervention should be strongly considered in children with HIV infection with FTT as it may have a positive impact on weight gains and morbidity of HIV infection. Furthermore, delays in institution of nutritional intervention should be minimized.