Abstract
The palatine tonsils are strategically positioned to monitor both airborn and alimentary antigens. The deep crypts make a massive antigenic and mitogenic load possible, and they contain the cells necessary to produce an antibody response. Seventeen sudden infant death syndrome (SIDS) cases and 9 age matched controls, were examined immunohistochemically with regard to the presence of IgA-, IgM-, IgD-, and IgG-, as well as for the subtypes IgG1-, IgG2-, IgG3-, and IgG4-immunocytes.
*p<0.01 vs. controls. Number of cells/0.1mm2 tissue area. No significant differences were demonstrated in the total number of IgM-, IgD-, IgG2- or igG4-immunocyte groups. The immune response was primarily in the germinal center and interfollicular area indicating a recent stimulation of the palatine tonsillar immune system. The IgG-subgroup response profile may indicate a viral protein antigen.
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Stoltenberg, L., Vege, Å., Saugstad, O. et al. 357 CHANGES IN THE CONCENTRATION AND DISTRIBUTION OF IMMUNOGLOBULIN PRODUCING CELLS IN SIDS PALATINE TONSILS. Pediatr Res 36, 62 (1994). https://doi.org/10.1203/00006450-199407000-00357
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DOI: https://doi.org/10.1203/00006450-199407000-00357