Abstract
Acute lymphoblastic leukaemia (ALL) was diagnosed in a 36-year-old and treated with cytarabin, daunorubicin, doxorubicin and cytarabin, thioguanin, respectively, in an unrecognized pregnancy at conception and at about 35-37 days p.c., Amniocentesis at 16 weeks of gestation revealed a normal female karyotype.
At delivery, brachycephaly, hypoplasia of supraorbital bony structures and hypotelorism were seen. Hypoplastic nasal root, bilateral choanal atresia and micrognathia caused hypoplasia of naso- and oropharynx. There was also bilateral aplasia of the radius and hypoplasia of the first ray of the hands. Internally, an atrial septal defect II could be demonstrated. The malformations detected are in accord with the timing of teratogenesis. Neurodevelopment is normal at the age of 8 months. Experience with the use of cytotoxic drugs in pregnancy has so far been limited to folate antagonists.
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Artlich, A., Môller, J., Tschakaloff, A. et al. TERATOGENIC EFFECTS IN A CASE OF MATERNAL TREATMENT FOR ACUTE LYMPHOBLASTIC LEUKEMIA (ALL). Pediatr Res 35, 260 (1994). https://doi.org/10.1203/00006450-199402000-00036
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DOI: https://doi.org/10.1203/00006450-199402000-00036