Abstract
Postocclusional oscillatory pressure transients after rapid flow interruption features additional parameters to the end-interruption resistance (RintEI). To detect changes in lung function during bronchial provocation tests in 10 healthy (age: 7 - 14 years) and 50 asthmatic children (age: 5 - 15 years) were studied. By such analysis the resonance frequency ω0, the damping factor d (time series), the resonance frequency Fps and the amplitude at FFS, the power factor AFS (frequency scries), can be obtained. Cumulative doses of inhaled carbachol (125, 250, 500, 750, 1000 μg) were administered and the variance-based provocation dose (PDvb) for ω0. FFS, Aps and RintEI were calculated. Significant mean changes during bronchial challenge were obtained for RintEI 10.6 ± 12.5 SD (53 %) in healthy, 7.5 ± 9.7 SD (54 %) in asthmatics, and for d 7.2 ± 9.4 SD (53 %) in healthy, 6.7 ± 7.1 SD (45 %) in asthmatic children respectively. With respect to sensitivity and specificity d was the most sensitive and specific parameter represented by a PDvb at a lower threshold (68 % at 345 μg) than RintEI (62 % at 708 μg) for carbachol. Moreover, reversibility after 800 μg salbutamol was better reflected by d (7.5 SD: p < 0.001) than by RintEI (3.0 SD). Analysis of postocclusional pressure transients after flow interruption could be a better estimate of the mechanics of the thoraco-pulmonary system, including the interaction of conducting properties of the airway and the inductive element given by the volume
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Kraemer, R., Frey, U. 117 ANALYSIS OF OSCILLATORY PRESSURE TRANSIENTS AFTER FLOW INTERRUPTION IN HEALTHY AND ASTHMATIC CHILDREN DURING BRONCHIAL CHALLENGE. Pediatr Res 36, 22 (1994). https://doi.org/10.1203/00006450-199407000-00117
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DOI: https://doi.org/10.1203/00006450-199407000-00117