Abstract
It has been suggested that plasma lactate (L) as an indicator of hypoxemia may identify serious anaemia requiring transfusion. One might expect anaemia to exacerbate the effect of hypoxemia with increased L resulting. The influence of haemoglobin (Hb) (range:3.2-9.6 g/100ml), glucose, weight, PaO2 and blood pressure on L (range:2.4-9.3 mmol/l) was studied in 31 piglets aged 12-60h. The animals were anaesthetised with halothane, intubated and sampled under stable conditions. 17 of the animals were sampled again after a period of severe hypoxemia (median PaO2=3.3kPa). Regression analysis were performed showing Hb to be the best predictor of L at base line conditions, (log L=1.1-0.1 Hb p=0.0001 Adj.R2=0.5). Hb did not however influence the amount of increase in L (ΔL) (range:10.6-28.9) during severe hypoxia. None of the recorded variables alone or in combinations were able to predict ΔL with p<0.05.
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Haaland, K., Kofstad, J. & Thoresen, M. 87 VARIABLES INFLUENCING THE LEVEL OF PLASMA LACTATE. Pediatr Res 36, 17 (1994). https://doi.org/10.1203/00006450-199407000-00087
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DOI: https://doi.org/10.1203/00006450-199407000-00087