Abstract
AIM: Combining D2O and DXA allows to assess 4 body compartments (body water, TBW; bone-free lean body mass, BLBM; bone, BMC; fat mass, FM) and to calculate the fat-free solids (proteins) as FFS=BLBM-TBW. We studied the feasibility in adults before the application to pediatric patients. The reference data are compared with TBW, FM and lean body mass (LBMDXA=BLBM+BMC) obtained by the popular, but indirect method of BIA (bio-impedance).
METH: Simultaneous measurements using D2O ([1]: oral load, 1.0 ml/kg, 2H serum enrichment after overnight fast), DEXA ([2]: QDR-1000W, Hologic, USA), BLA ([3]: Akern-101); 38 healthy males: 24±1 y, 719±11.4 kg, 178.4±7.1 cm. CV: TBW: 1% (±0.4 L), LBM: 1.5% (±1.0 kg), FM: 2% (±0.3 kg), BMC: 1% (±0.04 kg).
RES: Mean±sd of the ratio of TBW, BLBM, BMC, and FFS: a) percent BW, B) percent LBMDEXA; C) mean±sd of individual differences between D2O/DEXA and BIA (***): p < 0.001, paired t-test).
DISC: 1) Water content of LBM (D2O and DEXA) seems to be fairly constant, but slightly decreases with BW. 2) BIA significantly underestimates TBW and LBM with a systematic error and considerable individual variation.
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Fusch, C., Jensen, E. & Horber, F. 68 A 4-COMPARTMENT MODEL OF BODY COMPOSITION: COMBINING DEUTERIUM DILUTION (D20) WITH DUAL-ENERGY X-RAY ABSORPTION (DXA). Pediatr Res 36, 14 (1994). https://doi.org/10.1203/00006450-199407000-00068
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DOI: https://doi.org/10.1203/00006450-199407000-00068