Abstract
R-HuEpo is effective in preventing AOP. Low r-HuEpo doses (30 IU/kg), however, has not been effective. We speculate that the nourishment given during r-HuEpo treatment is essential for the actual haematological response.
In an ongoing open randomised study we have injected r-HuEpo to healthy preterm infants (ga < 31 weeks and bw < 1400) in doses of 100IU/kg and 50IU/kg thrice weekly from the age of three till the age of 7 weeks. All infants were fed human milk as base for their nourishment, in addition half of the infants in each dose group was given cow's milk protein (CMP or PRESEMP), the other half was given an equal amount of human milk protein (HMP), both groups to yield a protein intake of about 3.0 g/kg/day from week 3 untill week 8.
Preliminary data from 31 infants are reported: The four groups were similar regarding bw, ga, weight and haematological parameters at study entry (week 3).
The present data indicates that even 50IU/kg thice weekly prevents AOP in well inshed preterm infants. The source of protein (HMP or CMP) seems not to influence growth or the r-HuEpo induced haematological response.
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Bechensteen, A., Group, O. 17 DIFFERENT DOSES OF RECOMBINANT HUMAN ERYTHROPOIEITIN (R-HUEPO) AND DIFFERENT PROTEIN SOURCES IN THE TREATMENT OF ANAEMIA OF PREMATURITY(AOP). Pediatr Res 36, 5 (1994). https://doi.org/10.1203/00006450-199407000-00017
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DOI: https://doi.org/10.1203/00006450-199407000-00017