Abstract
ABSTRACT: Human parotid glands from 55 forensic autopsy subjects, 1–12 mo of age, were examined by immunohistochemistry without knowledge about the cause of death. Various combinations of monoclonal or polyclonal antibody reagents of the following specificities were applied in two-color immunofluorescence analyses: HLA class I or II (DR, DP, or DQ); pan-T cell (CD3); leukocyte common antigen (CD45); and secretory component (poly-Ig receptor). Sudden infant death syndrome victims (n = 17) were shown to have significantly increased numbers of CD45+ stromal leukocytes and intensified epithelial expression of HLA-DR and secretory component as well as increased endothelial expression of both HLA class I and II (DR, DP, and DQ) determinants compared with controls (n = 31) who had died from noninfectious causes. Seven overtly infectious subjects (bronchopneumonia) showed still more up-regulated expression. This result suggested that enhanced stimulation of the local immune system exists in sudden infant death syndrome, with release of certain cytokines that are known to up-regulate epithelial expression of HLA-DR and secretory component.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Thrane, P., Rognum, T. & Brandtzaeg, P. Up-regulated Epithelial Expression of HLA-DR and Secretory Component in Salivary Glands: Reflection of Mucosal Immunostimulation in Sudden Infant Death Syndrome. Pediatr Res 35, 625–628 (1994). https://doi.org/10.1203/00006450-199405000-00017
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-199405000-00017
This article is cited by
-
Altered gene expression and possible immunodeficiency in cases of sudden infant death syndrome
Pediatric Research (2016)
-
Gene variants predisposing to SIDS: current knowledge
Forensic Science, Medicine, and Pathology (2011)