Abstract
Recent research indicates that hypoxia precedes death in approximately 80% of the SIDS cases and that SIDS infants have a stimulated immune system at time of death. It has been shown in infants as well as in several experimental animal models, that CNS-maturity affects the effectiveness of autoresuscitation. It has been postulated that Il-1β may be the intermediary causing prolonged sleep apnea and SIDS during respiratory infections. To test this, 5-10 days old piglets were given 11-1β intravenously (n = 8) or intratechally (n = 9) prior to laryngeal stimulation with NH3, an agent known to cause apnea. The procedure was also tested in a control group (n=7). The duration of the apnea was recorded as well as the number of respirations in 2 min following apnea. Values are given as median and interquartile range.
We conclude that i.v. and i.Th. injection of Il - 1β effects, the length of apnea and the quality of autoresuscitation.
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Stoltenberg, L., Sundar, T., Almaas, R. et al. CHANGES IN APNEA AND AUTORESUSCITATION IN PIGLETS AFTER INTRAVENOUS AND INTRATECHAL INTERLEUKIN- 1ß INJECTION. Pediatr Res 35, 267 (1994). https://doi.org/10.1203/00006450-199402000-00078
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DOI: https://doi.org/10.1203/00006450-199402000-00078