Abstract
We have compared the changes in glucose concentration in dialysate and plasma and studied the effects on lipolysis in the subcutaneous adipose tissue with microdialysis during first the insulin and glucagon surge induced by arginin and thereafter under the insulin in fusion in 6 children. Before the test, the mean plasma and dialysate glucose levels were identical. During the arginin infusion, plasma glucose levels increased whereas the dialysate levels decreased. After insulin, the dialysate and plasma glucose decreased similarily; there was no delay in the dialysate. The stress induced a rapid increase in blood glucose levels but the increase in the dialysate was significantly delayed. The dialysate glycerol decreased during the arginin infusion. After insulin, no further decerease was found. Instead, all subjects showed an increased lipolysis. In conclusion, differences between interstitial and plasma glucose levels were due to a local insulin effect combined with a slow diffusion rate between blood and interstitium. The catecholamine surge induced by the hypoglycemia partly overcomes the antilipolytic effect of insulin.
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Marcus, C., Margery, V., Kamel, A. et al. EFFECTS OF ARGININ-INSULIN TOLERANCE TEST ON GLUCOSE AND GLYCEROL LEVELS IN PLASMA AND IN MICRODIALYSATE FROM THE SUBCUTANEOUS ADIPOSE TISSUE. Pediatr Res 33 (Suppl 5), S78 (1993). https://doi.org/10.1203/00006450-199305001-00450
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DOI: https://doi.org/10.1203/00006450-199305001-00450