Abstract
Understanding Turner syndrome spontaneous adult height is a prerequisite to an accurate assessment of the therapeutic efficiency of growth hormone treatment. The heights described in the literature reveal significant differences (136 to 147 cm). Our collaborative study pooled results from 16 pediatric endocrinology centers and obtained a great number of spontaneous adult heights (n = 216). The selective criteria were: chronological age (CA)>18 years, bone age (BA)>16 years, typical kariotype, no treatment with growth hormone nor anabolic steroids. Mean CA was 23.3 ± 5.6 years. Chromosomal anomalies were: monosomy X: 56.7%, mosaïcism: 32.7%, structural aberration: 10.6%. Mean adult height in the whole group was: 141.5 ± 6.6 cm). There was no significant difference as to monosomy X (141.1 ± 6.4 cm for n = 121); mosaicism (141.5 ± 7.5 cm torn = 72); anomaly X (141.4 ± 5.0 cm for n = 23).
Mean parental height was 170.4 ± 7.1 cm (father) and 160.1 ± 6.2cm (mother). Parental height and patients heights correlated significantly: more so with fathers' heights (r = 0.50) than with mothers' (r = 0.42). The correlation was still clearer with the target height (r = 0.55).
Individual patients heights varied greatly (ranged irom 129 to 161 cm). The analysis heights in the 2 groups: > 146.6 cm (+ 1 SDS) n = 34 and < 134.8cm (-1 SDS) n = 35 showed no difference in chromosomal anomaly distribution but revealed a very significant difference in parental height (158.3 ± 3.6 cm and 170.4 ± 4.9 cm respectively). These results showed: Turner syndrome adult heights were 4 SD below mean French heights, no difference in kariotype, a strong correlation with parental height and target height. Individual height differences can be explained by parental heights.
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Rochiccioli, P., Battin, J., Bertrand, A. et al. STUDY OF FINAL HEIGHT IN TURNER SYNDROME(N = 216). Pediatr Res 33 (Suppl 5), S59 (1993). https://doi.org/10.1203/00006450-199305001-00335
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DOI: https://doi.org/10.1203/00006450-199305001-00335