Abstract
The IGF autocrine/paracrine system is believed to play a major role in the regulation of human fetal growth. We have examined the ontogeny of IGF-I, IGF-II, IGFBP-1, 2, 3 concentrations in fetal development throughout gestation using cord sera from 97 normal newborns between 26 and 42 weeks. We also compared these variables with those from 18 SFD and 9 LFD newborns.
IGF-I and IGF-II were measured by RIA and ELISA after acid-ethanol extraction. IGFBP-1, 2, 3 were measured by ELISA newly deveoloped.
In relation to gestitional age and birth weight, IGF-I and IGFBP-3 had positive correlation and IGFBP-1 had negative correlation. IGF-II and IGFBP-2 did not show any correlation. In cord sera from SFD newborns the decreased IGF-I and IGFBP-3 levels and the increased IGFBP-1 levels were observed. In contrast, in LFD cord sera these variables were not significantly different from those of normals.
These results imply that these IGF-related peptides play significant role in human fetal growth by positive and negative regulatory mechanism. In contrast IGF-II and IGFBP-2 do not play a role in fetal growth during late stage of fetal development.
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Fujieda, K., Shinohara, N., Nakae, J. et al. IGFs AND IGF BINDING PROTEINS IN HUMAN CORD SERA: RELATIONSHIP TO INTRAUTEINE GROWTH. Pediatr Res 33 (Suppl 5), S36 (1993). https://doi.org/10.1203/00006450-199305001-00196
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DOI: https://doi.org/10.1203/00006450-199305001-00196