Abstract
We observed the body and bone composition changes in two adolescent GHRD patients receiving 120 ug/g of rhIGF-I twice daily sc. A GnRH analog was administered im once monthly. LHRH testing demonstrated a blunted response during therapy. All safety parameters remain within normal ranges. The main characteristics of the individuals at baseline and at a six months evaluation are provided: SUBJECT #1: Age 17 8/12vs18 2/12 y; Height 115.5vs119.6 cm; Weight 28.6vs30.8 kg; BMI 30.0vs21.5; Bone age 13vsl3 y; Body mass 28,604vs30,813 g; Lean mass 14,653v5l6,891 g; Fat mass 13,951vsl3,922 g; Fat percentage 48.8vs45.2 %; L/F ratio 1.05vs1.21; Body Calcium 326vs327; Total BHD 0.72vs0.83; Spine BMD 0.69vs0.70; Femur BMD 0.58vs0.63.
SUBJECT #2: Age 18vs18 6/12 y; Height 114.3vs118.4 cm; Weight 22vs21.7 kg; BMI 16.8vsl5.47; Bone age 3.6vs13.6 y; Body mass 22,009vs21,674 g; Lean mass 13,146vs14,830; Fat mass 8,863vs6,844; Fat percentage 40.3vs31.6 %; L/F ratio 1.48vs2.16 g; Body Calcium 224vs240 g; Total BMD 0.7vs0.7 g/cm2; Spine BMD 0.65vs0.55 g/cm2; Femur BMD 0.59vs0.67 g/cm2.
Two adolescent patients receiving concomitant therapy with rhIGF-I and a GnRH analog for six months, showed an increase in height without an advancement in bone age. Body compositions changes included a decrease in body mass index, increments in lean mass, decreases in fat mass with associated height L/F ratio. Despite a diminishment in spine BMD in patient #2, bone mineral accretion was observed, with increases in total body mineral an calcium content, as well as in total and regional bone mineral density.
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Guevara-Aguirre, J., Vasconez, O., Martinez, V. et al. CHANGES IN BODY AND BONE COMPOSITION IN ADOLESCENT GROWTH HORMONE RECEPTOR DEFICIENT (GHRD) PATIENTS RECEIVING rhIGF-I AND A GnRH ANALOG. Pediatr Res 33 (Suppl 5), S5 (1993). https://doi.org/10.1203/00006450-199305001-00017
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DOI: https://doi.org/10.1203/00006450-199305001-00017