Abstract
ABSTRACT: Psoriasis has been associated with an abnormal plasma lipid metabolism, and changes of erythrocyte membrane lipid composition and fluidity have been shown in adult patients. To investigate whether the alterations of plasma lipids appear also in pediatric patients, we have studied plasma lipids and lipoproteins in 15 prepubertal children affected by mild-to-moderate psoriasis with respect to healthy controls. The patients showed higher levels of plasma total cholesterol (4.44 ± 0.78 versus 4.03 ± 0.58 mmol/L), a significant increase of cholesterol associated with HDL (1.39 ± 0.26 versus 1.13 ± 0.28 mmol/L, p = 0.02), and a significant decrease of the ratio LDL cholesterol to HDL cholesterol (1.73 ± 0.6 versus 2.46 ± 0.8, p = 0.02). By using fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene, we have shown a significant increase in fluidity in erythrocyte membrane of psoriatic children that was associated with a slight, but not significant, decrease in the cholesterol to protein ratio (422 ± 127 versus 503 ± 117 nmol/mg). No significant changes of phospholipid fatty acid composition have been shown, in disagreement with previous studies in adult patients. Our results support the relation between childhood psoriasis and plasma lipid changes, which are likely related to the slight compositional changes in erythrocytes. However, the observed abnormalities are expressed differently in children than in adults.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ferretti, G., Simonetti, O., Offidani, A. et al. Changes of Plasma Lipids and Erythrocyte Membrane Fluidity in Psoriatic Children. Pediatr Res 33, 506–509 (1993). https://doi.org/10.1203/00006450-199305000-00017
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-199305000-00017
This article is cited by
-
Characterization of Lipoprotein Composition and Function in Pediatric Psoriasis Reveals a More Atherogenic Profile
Journal of Investigative Dermatology (2016)
-
Comparative Study of the Expression of ATF-3 and ATF-4 Genes in Vessels Involved into Atherosclerosis Process and in Psoriatic Skin
Bulletin of Experimental Biology and Medicine (2011)
-
Metabolic disorders in patients with psoriasis and psoriatic arthritis
Current Rheumatology Reports (2006)