Abstract
Background: The influence of Aminophylline on cerebral perfusion and metabolism in premature infants is controversial. Cytochrome c oxidase is an indicator of aerobic energy production in the cell and can be monitored in the neonatal brain by near infrared spectroscopy (Jöbsis, 1977; Wyatt, 1989).
The aim of this study was to investigate the change of oxidised cytochrome c oxidase in the brain of premature infants after a bolus injection of 6 mg Aminophylline per kg body weight administered within 1 to 2 minutes to facilitate weaning from the respirator.
Patients: 13 premature infants (gestational age 26 to 34 weeks, postnatal age 1 to 7 days, birth weight 760 to 2300 g).
Results: Values are means (SD). ΔCBV: change of cerebral blood volume, ΔCyt: change of oxidised cytochrome c oxidase, *:p<0.02.
Conclusion: Aminophylline reduces cytochrome c oxidase significantly in the brain of premature infants and seems to interact with energy metabolism.
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Hans-Ulrich, B., Martin, W., Matthias, K. et al. AMINOPHYLLINE REDUCES CYTOCHROME C OXIDASE IN THE BRAIN OF PREMATURE INFANTS. Pediatr Res 32, 613 (1992). https://doi.org/10.1203/00006450-199211000-00049
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DOI: https://doi.org/10.1203/00006450-199211000-00049