Abstract
The statural growth of 49 children (29 F, 20 M) with CAH by deficit of 21-CH was analyzed. Mean age (mCA) upon diagnosis was 37.4 days (48 hs–9m) for 24 patients (48.9%) with salt wasting CAH (CAHsw) and 4.85 yr (13d–19yr) for 25 patients (51.02%) with simple virilizing CAH (CAHsv). Standard deviation scores (SDS) were analyzed for height (Tanner) and Bone Age (Greulich and Pyle). The group of CAHsv was subdivided into three age groups: 1)9 pat < of 6m: mCA 41 days (13d–4.5m): 2)11 pat.< of 10 yr: mCA 4.78 yr (2.5 yr–6.11 yr) and 3)5 pat.> of 10 yr MCA 12.19 yr (10.6 yr–19 yr). A follow up period of 4.75 yr (1.3 yr–16.8 yr) was done in 41 patients (83.7%). SDS of height in CAHsw group diminished significantly from −1.62±1.99 (−5.23/+2) to −0.84±1.49) (−2.48/+2.76) at the last control. For CAHsv group the results were:
Mean differences of BA for CA ware −0.11 yr at diagnosis and −0.09 yr at the last visit in CAHsw. In CAHsv in two age groups analyzed: 1) < 6m: diminished from – −0.12 yr to −0.16 yr and 2) < 10 y: from +5.05 yr to +3.8 yr. Conclusions: Decreasing differences in SDS of height for CA ware observed in both groups. They resulted significant in patients with CAHsw and group 2 of CAHvs. BA was not modified in children with CAHsw or CAHsv diagnosed before 6 months of age. Older children decreased their accelerated BA in 1.25 years during the period analyzed.
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Miras, M., Martín, S., Miñoz, L. et al. 23 STATURAL GROWTH AND SKELETAL MATURATION IN CHILDREN WITH CONGENITAL ADRENAL HYPERPLASIA (CAH). Pediatr Res 32, 253 (1992). https://doi.org/10.1203/00006450-199208000-00046
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DOI: https://doi.org/10.1203/00006450-199208000-00046