Abstract
ABSTRACT: An oral load of 20 mg/kg galactose produces significant changes in the 31P magnetic resonance spectrum of the liver of a galactosemic patient. The peak at 5.2 ppm (which includes inorganic phosphate and galactose-1 -phosphate) increased on two occasions to about twice its original size 60 min after galactose administration. An oral load of 10 mg/kg galactose given to a second patient produced no discernible changes at 30 min. We have also used an animal model of galactose intolerance, in which galactose metabolism in rats was blocked by the acute administration of ethanol. Studies in vivo and in vitro showed that the increase in the peak at 5.2 ppm was largely due to galactose-1-phosphate. We have shown in this preliminary study that small amounts of galactose can produce significant elevation of hepatic galactose-1-phosphate, which can be detected by 31P magnetic resonance spectroscopy.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kalderon, B., Dixon, R., Rajagopalan, B. et al. A Study of Galactose Intolerance in Human and Rat Liver In Vivo by 31P Magnetic Resonance Spectroscopy. Pediatr Res 32, 39–44 (1992). https://doi.org/10.1203/00006450-199207000-00008
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-199207000-00008
This article is cited by
-
In vivo study of brain metabolism in galactosemia by1H and31P magnetic resonance spectroscopy
European Journal of Pediatrics (1995)
-
Galactose-1-phosphate in the pathophysiology of galactosemia
European Journal of Pediatrics (1995)
-
31P magnetic resonance spectroscopy of the liver in an infant with galactosaemia
MAGMA Magnetic Resonance Materials in Physics, Biology, and Medicine (1993)