Abstract
ABSTRACTS: We evaluated bone mineralization by single photon absorptiometry at 2 y in a cohort of preterm infants studied since birth. Infants were fed human milk fortified with Ca [to achieve 80 mg/dL (19.96 mmol/L)] and P [40 mg/dL (12.91 mmol/L)] from wk 2 through 8 after birth. After hospital discharge, infants were divided into two groups (HM and F) determined by the timing of the introduction of cow milk-based formula. Mid-radius bone mineral content (BMC) was assessed in 10 infants who were breast-fed (HM) for a minimum of 2 mo after hospital discharge and 11 who were bottle-fed (F). The mean duration of human milk-feeding differed by design between HM and F groups (31 ± 15 versus 11 ± 3 wk, respectively). Although we had observed previously that group F had significantly greater BMC values at 16, 25, and 52 wk compared with values in group HM, we found similarities in BMC values (180 ± 30 mg/cm) between groups at 2 y. The 2-y cohort comprised healthy infants and the groups had similar birth weights, lengths of gestation, and values for weight (10.8 ± 1.1 kg), length (82 ± 2 cm), and bone width (7.8 ± 1.1 mm). Follow-up outcomes at 2 y in preterm infants fed fortified human milk in hospital suggest that if they continue to receive human milk after hospital discharge, radios BMC will “catch-up” to that of similar infants given formula in the posthospitalization period.
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Schanler, R., Burns, P., Abrams, S. et al. Bone Mineralization Outcomes in Human Milk-Fed Preterm Infants. Pediatr Res 31, 583–586 (1992). https://doi.org/10.1203/00006450-199206000-00009
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DOI: https://doi.org/10.1203/00006450-199206000-00009
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