Abstract
Plasma prekallikrein (PK) and kallikrein inhibition (KKI) values together with plasma kallikrein (KK) activity were measured with a chromogenic substrate (S-2302) in 13 RDS babies and 9 premature controls the first three days after birth. (Mean gestational age 28.7 (SD 2.1) and 28.9 (SD 1.8) weeks respectively). Further, high molecular weight kininogen (HK) (band I) and its degradation products (bands II and III) were studied by immunoblotting. Mean values (SD) the second day after birth:
PK, KKI, and total HK was lower in RDS than in controls during the study period. This indicates activation of the kallikrein-kinin system. The fraction of degraded HK (band III) is high during such activation. In RDS babies this fraction decreased from a high level, in mean 18%, to 2% (normal level) (p<0.01) from day 1 to day 2 indicating a possible reduction in activation of the kallikrein-kinin system.
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Saugstad, O., Buø, L., Johansen, H. et al. 178 ACTIVATION OF THE KALLIKREIN-KININ SYSTEM IN RDS. Pediatr Res 30, 657 (1991). https://doi.org/10.1203/00006450-199112000-00208
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DOI: https://doi.org/10.1203/00006450-199112000-00208