Abstract
In a previous study we found a large inter-individual variability between the BG level and EGPR. In the present study we have measured the response of EGPR to a change in BG level in individual LBW infants.
Patients: Four infants were studied solar. Gestational age ranged from 30 to 39 weeks, and birthweight from 1.5 to 2.1 kg. Increase of BG level was obtained by increasing the glucose infusion rate from 3.4 to 6.7 mg/kg/min, prior to the increase a small bolus of glucose was given. Studies were done prior to oral feeding. EGPR was measured with the prime dose, constant rate infusion technique, using 66, [2H2] glucose as a tracer.
Results: Before the change in BG level, BG was 3.5 mmol/l (mean), glucose turnover was 5.6 ±0.5 mg/kg/min. EGPR was 2.2 ± 0.2 mg/kg/min. After the change of BG. BG level was 5.7 mmol/l (mean), glucose turnover increased to 7.7± 1.0 mg/kg/min. The decrease of EGPR ranged from 13 to 100 %. This decrease was not related to the BG level, but was correlated to.the relative increase of BG (r=0.99, p=0.006)
Hypothesis: An increase of BG level induces a decrease ol EGPR, the degree ol decrease is related to the relative change of BG.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Baarsma, R., Reijngoud, DJ., Berger, R. et al. 81 RESPONSE OF ENDOGENOUS GLUCOSE PRODUCTION (EGPR) TO A CHANGE IN BLOOD GLUCOSE (BG) LEVEL IN LOW BIRTH WEIGHT (LBW) INFANTS ON THE FIRST DAY OF LIFE. Pediatr Res 30, 641 (1991). https://doi.org/10.1203/00006450-199112000-00111
Issue Date:
DOI: https://doi.org/10.1203/00006450-199112000-00111