Abstract
The effect of hypoxemia (HO, 10% O2) with and without hypovolemia (HV, bleeding 20% 20 min (20') after HO) on cerebral blood flow (CBF) was studied in 14 newborn piglets with the microsphere method. Surgery and experiments were performed under general anesthesia with 70% N2O. The piglets were ventilated paralyzed with pancuronium. CBF was measured in brainstem (BR), cerebellum (CE) and cerebrum (CR) at baseline (BS), during HO and after HV, and 30 (30') and 60 min (60') after HO. Results were (ml/100g/min, mean ± SD.):
HO significantly increases CBF. HV following HO reduces blood flow significantly in both CE and CR compared to BS. BR seems more stable to this insult.
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Odden, JP., Farstad, T., Hall, C. et al. 175 CEREBRAL BLOOD FLOW DURING EXPERIMENTAL HYPOXEMIA WITH AND WITHOUT HYPOVOLEMIA IN THE NEWBORN PIGLET. Pediatr Res 28, 306 (1990). https://doi.org/10.1203/00006450-199009000-00199
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DOI: https://doi.org/10.1203/00006450-199009000-00199