Abstract
The effects of the hypoxanthine (Hx)-xanthine oxidase (XO) system on the pulmonary circulation and prostanoid synthesis in young pigs were investigated. The pulmonary blood-flow and pressures were recorded continuously, and the cyclooxygenase metabolites TxB2 and 6 keto PgFla measured at regular intervals (RIA). Five groups were studied: 1)Pigs given XO bolus dose IU/kg into the right atrium. 2)Pigs pretreated with Hx 10 mmol/l before XO. 3)Pigs given indomethacin 7.5 mg/kg and XO. 4)Pigs given allo-purinol 50 mg/kg and XO. 5)Pigs given catalase 25,000 U/kg and XO during experiments. The table shows relative increase from baseline levels 25 min after XO, when maximum pulmonary vasoconstriction (PVR), was recorded. (±SD) * p< 0.05 ** p< 0.01 vs group 1
The study shows marked PVR increase in groups 1 and 2. This effect was attenuated in groups 3,4 and 5 where prostanoid changes were minimal. We therefore speculate that oxygen radicals trigger the arachidonate acid cascade to induce the described PVR respons.
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Sanderud, J., Bjoro, K. & Saugstad, O. 171 OXYGEN METABOLITES INITIATE PROSTANOID SYNTHESIS AND PULMONARY VASOCONSTRICTION IN YOUNG PIGS. Pediatr Res 28, 305 (1990). https://doi.org/10.1203/00006450-199009000-00195
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DOI: https://doi.org/10.1203/00006450-199009000-00195