Abstract
PM suffering from late metabolic acidosis often show growth failure. In a prospective randomized study in all PM below 1500 g as well as in all PM and newborns after intensive care therapy with max H+ (urine pH < 5.4 on two succeeding days), the influence of oral alkali therapy on the increase of BW was investigated. Group B received 2 mmol NaHCO3/kg/d for 7 days; group A (controls) was retrospectively divided into A1 (urine pH < 5.4 on 7 days) and A2 (urine pH > 5.4 for > 1 day). The results of net acid excretion (NAE. raraol/kg/d, 1.day) and of increase of BW (g, 1.-7.day) in 2 classes of PM (kg on 1.day) are:
The diminished increase of BW in PM with max H+ and similar caloric intake is a strong argument for our hypothesis that prolonged spontaneously occuring max H+ without manifest metabolic acidosis (blood pH > 7.28; BE > -8 mmol/L) decreases growth velocity.
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Kalhoff, H., Diekmann, L., Stock, G. et al. 31 EVIDENCE FOR DIMINISHED INCREASE OF BODY WEIGHT (BW) IN PREMATURES (PM) DURING PROLONGED SPONTANEOUSLY OCCURRING MAXIMAL RENAL ACID STIMULATION (MAX H+). Pediatr Res 28, 282 (1990). https://doi.org/10.1203/00006450-199009000-00055
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DOI: https://doi.org/10.1203/00006450-199009000-00055