Abstract
Indomethacin treatment causus renal dysfunction probably secondary to impairment of renal blood flow. We measured renal artery blood flow velocity (RBFV) in 15 preterm infants with symptomatic patent ductus arteriosus before and during the first 12 h after a single intravenous dose of 0.1 mg/kg of Indomethacin. RBFV was serially measured by Color-Doppler Flow Imaging and was used as a relative measure of changes in renal blood flow.
Indomethacin treatment led to a sharp decrease in RBFV, which was maximal at 10 min post-indomethacin and was followed by a slow recovery until baseline values were attained at 4 h. RBFV (mean ± SD) decreased from 25.2 ± 1.9 cm/sec pre-indomethacin to 15.2 ± 3.1 cm/sec at 10 min. and rose 22.3 ± 2.2 cm/sec at 2 h. Mean arterial pressure, heart rate, PaO2 and PaCO2 were stable during the study period. Plasma-Creatinine (mean ± SD) rose from 82 ± 18 umol/inl pre-indomethacin to 95 ± 20 umol/ml post-indomethacin with a decrease in urine production.
We conclude that indomethacin can impact on renal circulation of the preterm infant for a period of 2 h.
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Van Bel, F., Van De Bor, M., Guit, G. et al. 14 THE DURATION OF INDOMETHAC IN-INDUCED RENAL BLOOD FLOW DISTURBANCES IN PREMATURE INFANTS; ASSESSMENT WITH . COLOR-DOPPLER FLOW IMAGING. Pediatr Res 28, 279 (1990). https://doi.org/10.1203/00006450-199009000-00038
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DOI: https://doi.org/10.1203/00006450-199009000-00038