Abstract
Chloride (Cl) transport, deficient in CF, may be prostaglandin (PG) sensitive. Furthermore, exogenous pancreatic enzymes (PEs) are acid labile. The PGE1 analog EN increases gut pH within minutes of oral administration. We report a double-blind, placebo (P) controlled crossover study of EN, 4-8 ug/kg/day, in 20 CF Pts who required PEs to control steatorrhea. Ten Pts (Gp I, ages 5-23) were treated for 3 days and ten (Gp II, ages 5-14) for 13 days. We examined: stool (ST) fat, sodium (Na), potassium (K) and chloride (CI); ST weight (WI), frequency (F) and osmolality; sweat (SW) C1, Na, K; essential fatty acids (EFA).
Results (mean ± SEM):
There were no significant differences in ST or SW electrolytes, or EFA between the two treatments for CpI or GpII. Conclusions: EN increases fat absorption in CF Pts when treated for 13 days but not when treated for 3 days. Long term adaptive responses to PGs, rather than enzyme sparing from short term changes in luminal pH, likely underlie our findings.
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Lloyd-Still, J., West, M., Powers, C. et al. ENISOPROST (EN) IMPROVES FAT ABSORPTION IN CYSTIC FIBROSIS (CF) PATIENTS (PTS). Pediatr Res 27, 541 (1990). https://doi.org/10.1203/00006450-199005000-00098
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DOI: https://doi.org/10.1203/00006450-199005000-00098