Abstract
The auditory brainstem response (ABR) has proven an objective noninvasive neurophysiological tool in the assessment of peripheral and central auditory pathway integrity and maturation. These functions might be affected by intrauterine exposure to heroin.
ABR testing was performed in 17 infants of heroin-addicted mothers (GA 34.4 ± 3.6 wks, BWT 2020 ± 710 gm) during the neonatal period. Hearing acuity was assessed by threshold determination and found normal for age in all infants. Auditory pathway integrity and maturation were assessed by wave I, V and I-V interpeak latency measurements. Waves I and V were bilaterally prolonged for age In 5 Infants (29%), all preterm when tested. This finding seems consistent with (transitory) middle ear dysfunction described in this age group. Central conduction time (I-V interval) was within normal limits for gestational age in all infants.
Intrauterine exposure to heroin, therefore, does not seem to significantly affect peripheral and central auditory pathway integrity and maturation. Drug effects might, however, be masked by the influence of perinatal clinical events on the ABR.
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Lohrer, R., Aust, G., Coen, R. et al. AUDITORY BRAINSTEM RESPONSES IN INFANTS OF HEROIN-ADDICTED MOTHERS. Pediatr Res 26, 519 (1989). https://doi.org/10.1203/00006450-198911000-00117
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DOI: https://doi.org/10.1203/00006450-198911000-00117