Abstract
Collaborative European Multicenter Study Group in the period 1985-88, a total of 164 babies with severe RDS (requiring artificial ventilation with ≥60% oxygen) were treated with porcine surfactant (Curosurf) in a collaborative project involving neonatal intensive care units in France, Holland, Northern Ireland, Italy, Sweden and West Germany. The first 77 patients were part of a controlled trial; the following 87 patients were treated without controls since the benefit of the replacement therapy had already been established (Pediatrics 82:683, 1988). Both series of patients showed a > 100% sustained improvement of the a/APO2 ratio after receiving surfactant, and the number of surfactant-treated babies surviving without chronic lung disease remained twice as high as in the earlier control group (55% vs 26%; P < 0.001). Factors with a negative impact on the therapeutic response include low birthweigt, perinatal asphyxia, and high oxygen and ventilator pressure requirements. One year follow-up data from the controlled study indicate no increased incidence of neurodevelopmental handicap among survivors in the surfactant-treated group.
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Robertson, B. SHORT-TERM CLINICAL RESPONSE AND FOLLOW-UP IN 164 BABIES TREATED WITH PORCINE SURFACTANT (CUROSURF) FOR SEVERE NEONATAL RESPIRATORY DISTRESS SYNDROME (RDS). Pediatr Res 26, 512 (1989). https://doi.org/10.1203/00006450-198911000-00077
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DOI: https://doi.org/10.1203/00006450-198911000-00077