Abstract
Insulin and IGF-1 are structurally very similar and there are many functional links between the two hormone systems. However normal relationships between insulin and IGF-1 have never been defined. We performed intravenous glucose tolerance tests (0.5g/g/ maximum 25g) on 59 islet-cell antibody negative siblings of diabetic children and on 43 adults (aged 5.6-50 years). Puberty was staged (Tanner) and subjects divided into 4 groups: I - stage 1 (n=22), II - stages 2 & 3 (n=17). III - stages 4 & 5 (n=20), IV - adults >17 years (n=43). The pattern of fasting IGF-1 concentrations, fasting insulin and incremental 0-60 minute insulin areas (following IV glucose) in Groups I to IV was markedly similar levels rose significantly throughout puberty (p<0.001 for all parameters) and declined to prepubertal levels by the third decade. IGF-1 concentrations: I - 0.85±0.44, II - 1.72±0.81, III 2.35±0.83, IV - 1.11±0.51 U/ml. Fasting insulin concentrations: I - 7.5±3.2, II - 13,6±5.0, III - 13.8±3.3, IV - 7.6±2.9 mU/l. Incremental 0-60 minute areas: I - 1163±433, II - 2047±668, III - 2441±675, IV - 1117±485 mU/l/min. There was a strong positive correlation between logged insulin and logged IGF-1 levels; fasting insulin versus IGF-1 concentrations r=0.625, p<0.001 incremental 0-60 min areas versus IGF-1 concentrations r=0.572 p<0.001. This relationship, constant from 5 to 50 years, suggests that insulin may have an important influence on growth during childhood.
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Smith, C., Dunger, D., Taylor, A. et al. 113 RELATIONSHIP BETWEEN BASAL AND STIMULATED INSULIN RESPONSES AND INSULIN-LIKE GROWTH FACTOR 4 (IGF-1) IN NORMAL SUBJECTS AGED 5 TO 50 YEARS. Pediatr Res 24, 536 (1988). https://doi.org/10.1203/00006450-198810000-00134
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DOI: https://doi.org/10.1203/00006450-198810000-00134