Abstract
In isolated GH deficiency, a too insufficient height at onset of a puberty leads to reduced adult height. In order to prevent this we have tried the efficiency of LHRH analogue in association with GH in such cases.
Long-acting Trp 6 LHRH analogue (LHRHa) was used in 4 male patients aged 12 to 16 years, treated with hGH 20 IU/kg/yr from 1 to 6 years for isolated GH deficiency. LHRHa was injected IM monthly (3.7 mg in 2 patients, 1.8 in 2) from the onset of pubertal stage P2. The mean ± SD data before and after 12 months of LHRHa therapy were as follows : growth velocity (SDS) decreased from -1.79 ± 0.34 to -1.93 ± 0.46 for chronological age and increased from -0.80 ± 0.90 to -0.55 ± 1.11 for bone age; plasma testosterone (ng/ml) decreased from 1.95 ± 0.77 to 0.10 ± 0.05; ratio of bone age to height age (BA/HA) decreased from 1.12 ± 0.12 to 1.05 ± 0.10.
Though preliminary, these results seem encouraging. Treatment with LHRHa allowed maintenance of plasma testosterone at pre-pubertal levels. Since control studies in pubertal patients with isolated GH deficiency treated with hGH alone showed an insufficient growth spurt, it is likely that the association of LHRHa with hGH may allow the improvement of final height.
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Toublanc, J., Garnier, P., Couprie, C. et al. EFFECT OF LHRH ANALOGUE IN PUBERTAL PATIENTS WITH ISOLATED GROWTH HORMONE DEFICIENCY. Pediatr Res 23, 117 (1988). https://doi.org/10.1203/00006450-198801000-00098
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DOI: https://doi.org/10.1203/00006450-198801000-00098