Abstract
Tauro-conjugated BA, which are predominant during development, are more polar and more resistant to passive intestinal absorption than G-conjugated. To further elucidate the possible impact of postnatal BA conjugation pattern on the dynamic of enterohepatic circulation, we have studied 16 premature formula-fed infants (29-36 gw): at the age of 2 weeks, they were randomly assigned to receive an adapted formula(F)with or without T (25μmol/dl). Before and after 4 weeks of this diet, fasting serum levels of cholic (CA) and chenodeoxycholic (CDCA) acids were determined by competitive solid phase enzyme immunoassay, after TLC separation of the G and T conjugated forms.
The predominance of G-conjugates (mainly of CA)in serum of prematures, contrasts with the reported excess of T-conjugated BA in their duodenal fluid and may be due to later appearance of the active ileal transport system, for which T-conjugates are almost exclusively dependent to be absorbed. T-feeding produced a slight change in the relative proportion of G and T conjugates in serum, which seems limited to CA, in agreement with the “in vitro” observation of higher synthesis of conjugates for CA than CDCA. The sensible decrease of serum CA levels after T supplementation may be related to the inability of prematures to absorb increased amounts of tauro-CA, while extensive passive absorption would permit conservation of the more hydrophobic CDCA.
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Colombo, C., Roda, A., Grigolo, B. et al. 92 SERUM GLYCINE (G) AND TAURINE (T) CONUGATED BILE ACIDS (BA) IN PREMATURE FORMULA-FED INFANTS BEFORE AND AFTER TAURINE SUPPLEMENTATION. Pediatr Res 24, 420 (1988). https://doi.org/10.1203/00006450-198809000-00115
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DOI: https://doi.org/10.1203/00006450-198809000-00115