Abstract
During central precocious puberty (CPP) elevated plasma Sm-C/IGF I levels have been observed, with a significant decrease during short term suppression by LHRH analogues (LHRHa). The present study was designed to evaluate the course of Sm-C after a prolonged and complete suppression of gonadal activity. 16 children (13 girls and 3 boys) with idiopathic (n=11) or organic (n= 5) CPP were fully controlled by Buserelin, 20-30 μg/kg/d sc for a period up to 3 years. At onset of therapy their mean CA was 6 4/12 ± 6/12 yr with a mean BA advance of 3 10/12 ± 6/12 yr and gonadal activity with vaginal maturation index (VMI)>35, E2>25 pg/ml in girls, T>1 ng/ml in boys and normal GH secretion. The Sm-C values from time of full control (VMI< 35 or T < 0.5 ng/ml) are as follows, by comparison to growth rates (m ± sem)
Sm-C values reached normal for CA prepubertal values only 24-36 mo after full suppression of gonadal activity. This was correlated with growth changes (p<0.05)
In conclusion 1) these data show that a long time is necessary before full return to normal for CA of plasma Sm-C, 2) a positive correlation between Sm-C and growth favours the role of GH and Sm-C in the pubertal growth spurt, 3) the return of Sm-C to normal values for CA is an additional indication of control by LHRHa therapy.
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Crosnier, H., Brauner, R., Prévot, C. et al. PLASMA Sm-C AND GROWTH RETURN TO NORMAL VALUES IN CHILDREN TREATED BY LHRH ANALOGLE FOR TRUE PRECOCIOUS PUBERTY. Pediatr Res 23, 113 (1988). https://doi.org/10.1203/00006450-198801000-00072
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DOI: https://doi.org/10.1203/00006450-198801000-00072