Abstract
Measurement of disaturated phosphatidylcholine(DSPC) or phosphatidylglycerol(PG) have been proved to be useful in complicated mothers for evaluating the fetal lung maturity. But the procedure is complicated and takes long time. Kuroki et al.(Ped Res 19: 1017, 1985) described a simple immunoassay of the surfactant apoprotein having MW of 36 KDa and came up with an immunoassay kit incooperated with TEIJIN inst. With this kit, determination can be done within 1 h. We conducted this study to assess the clinical usefulness of this immunoassay kit (kindly provided from TEIJIN inst.)in the evaluation of fetal lung maturity. Twenty-six amniotic fluid samples were examined for levels of surfactant apoprotein, as well as DSPC, and PG. Results were as follows;
The amount of apoprotein was in a statistically significant correlation with gestational age as well as DSPC and PG.
This assay kit will provide rapid and accurate information about fetal lung maturity in the clinical field.
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Nakamura, H., Motoike, T., Sano, K. et al. 107: DETERMINATION OF SURFACTANT APOPROTEIN AND PHOSPHOLIPIDS IN AMNIOTIC FLUID FOR ESTIMATING FETAL LUNG MATURITY. Pediatr Res 24, 277 (1988). https://doi.org/10.1203/00006450-198808000-00132
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DOI: https://doi.org/10.1203/00006450-198808000-00132