Abstract
50 children with PP, 37 girls aged (mean ± SD) 6.6 ± 2.2 and 13 boys aged 7.6 ± 3.1 years, were treated for 30 months with monthly muscular injections (60 μg/kg) of DTrp 6, which normalized plasma gonadotropin and sex steroid levels. Before treatment mean height and bone ages were respectively 8.0 ± 2.6 and 9.1 ± 2.5 years in girls (HA/BA = 0.88 ± 0.1), 8.4 ± 3.1 and 8.9 ± 3.2 in boys (HA/BA = 0.93 ± 0.1). Height velocities (HV) were 10.8 ± 3.6 cm in girls, 11.0 ± 3.5 cm in boys. During the first 6 months HV and skeletal maturation remained accelerated and the HA/BA ratio decreased : 0.87 ± 0.1 in girls, 0.91 ± 0.09 in boys. After 6 months, HV decreased significantly to 5.5 ± 2.0 cm/year in girls (p<0.001) and 5.7 ± 1.6 in boys (p<0.005) while skeletal maturation decreased abruptly leading to a progressive and significant increase of HA/BA ratio reaching at 30 months 0.97 ± 0.08 in girls (p<0.001) and 1.04 ± 0.08 in boys (p<0.025). Mean growth hormone peak after ornithine was 13.6 ± 1.4 ng/ml before Trp 6, 12.3 ± 2.6 ng/ml after (NS) in both sexes and no correlation was found between plasma somatomedin C levels and HV. This data indicates that, in children of both sexes with PP, the perfect control of gonadotropin and gonadal secretions obtained by DTrp 6 leads, after a short delay, to a significant improvement of height prognosis.
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Couprie, C., Lacaille, F., Toublanc, J. et al. LINEAR GROWTH AND SKELETAL MATURATION IN CHILDREN WITH PRECOCIOUS PUBERTY (PP) TREATED BY A LONG-ACTING PREPARATION OF DTrp 6 LHRH (Trp 6). Pediatr Res 23, 113 (1988). https://doi.org/10.1203/00006450-198801000-00069
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DOI: https://doi.org/10.1203/00006450-198801000-00069