Abstract
Hypoxemia may result in tissue hypoxia and increased production and excretion of adenine triphosphate (ATP) degradation intermediates and uric acid (UA). If this hypothesis is correct, then adenine nucleotide degradation should diminish following increased delivery of oxygen to hypoxic tissues. Five patients with clinically stable COPD were infused with [8-14C]adenine to radiolabel the adenine nucleotide poool. Cumulative 3 days radioactivity excretion and urinary hypoxanthine (Hx), xanthine (X), UA and total purines (TP=sum of Hx, X and UA) were measured to assess purine nucleotide degradation before and after inhalation of oxygen (FiO2, 24%) for 4 days. Results (mean±SEM) were compared to those obtained in 4 normal subjects
The increased basal excretion of 14C and urinary purines in COPD patients suggest that hypoxemia accelerates adenine nucleotide degradation. The decrease in these parameters elicited by oxygen therapy lends further support to the hypothesis.
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Mateos, F., Gómez, P., Puig, J. et al. 84 ENHANCED ADENINE NUCLEOTIDE DEGRADATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD): THE EFFECT OF OXYGEN THERAPY. Pediatr Res 24, 125 (1988). https://doi.org/10.1203/00006450-198807000-00108
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DOI: https://doi.org/10.1203/00006450-198807000-00108