Abstract
Among 6997 patients admitted to the Institute of Rheumatology of the university of Rome 33 had aseptic necrosis of bone. one patient had polycytemia. In the remaining 32 patients no etiology could be established. Associated rheumatic diseases in the idiopathic group are shown in the table.
The male female ratio was 12:20 with a mean age of 50.2 years (range 10-82). Eight patients (6 with rheumatoid arthritis, 1 with progressive systemic sclerosis and 1 with asthma) received corticosteroids more or less regularly for at least 1 year before aseptic necrosis was diagnosed. one patient had diabetes mellitus, 6 had significant hypertension and 5 admitted excessive alcohol intake. Serum urate concentration has been determined in 27 of the 32 patients. Hyperuricemia was present in 4 of 19 women and in the four male gouty subjects. affected bones in the gouty patients were the femoral head (2 patients), the II metatarsal and the lunate. in kienbock's disease marked osteoporosis of the wrist was observed simulating a monoarthritis of different etiology.
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Ginconelio, A., Zoppini, A., Sorgi, M. et al. 43 HYPERURICEMIA, GOUT AND IDIOPATHIC ASEPTIC NECROSIS OF BONE. Pediatr Res 24, 118 (1988). https://doi.org/10.1203/00006450-198807000-00067
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DOI: https://doi.org/10.1203/00006450-198807000-00067