Abstract
A retrospective study of 49 patients with/or suspected for an immune disease was done to enable a comparision between levels of purine enzymes in mononuclear cells and some frequently used markers of immune function. A new observation was the finding of correlation between low ecto-5′nucleotidase activity and decreased T lymphocyte function measured as decreased lymphocyte proliferation after mito- and antigenic stimulation in vitro. In this study we did not find correlation between the activity of ecto-5′nucleotidase and the other investigated markers of immune function (lympfocyte count, lymphocyte subpopulations, concentration of immunoglobulines in serum and lymphocyte proliferation after mito- and antigenic stimulation in vitro). The activities of adenosine deaminase and purine nucleoside phosphherylase in mononuclear cells were also measured. In this group of patients no correlation was find between the activities of these enzymes and the investigated markers of immune function.
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Christensen, L., Nygaard, P., Mejer, J. et al. 21 DETECTION OF LOW ECTO-5′ NUCLEOTIDASE ACTIVITY IN MONONUCLEAR CELLS FROM PATIENTS WITH DEFECT T LYMPHOCYTE FUNCTION. Pediatr Res 24, 114 (1988). https://doi.org/10.1203/00006450-198807000-00045
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DOI: https://doi.org/10.1203/00006450-198807000-00045