Abstract
The study comprised 194 children and adolescents with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Blood sample for IAA, both conventional. (IF-ICA)- and complement fixing (CF-ICA) islet-cell antibodies uas drawn before the first insulin injection and the data were analysed together with some clinical, parameters. Coxsackie-B4- and mumps-virus specific antibodies (IgG, IgM and IgA) wero measured at diagnosis and 2 months after. Definition for a recent viral infection was based on high IgM, IgG and IgA antibodies or fourfold increase in paired serum samples.
Sixty-one children (31.4%) had an insulin-binding exceeding that (2.8%) of 68 matched controls and 45 (73.8%) of them were positive for IF-ICA (p<0.01) and 32 for CF-ICA. Subjects with IAA were younger than IAA-negative patients (7.1 ± 0.5 vs.9.3 ± 0.3(±SEM);p< 0.001). IAA did not show any significant association to other endocrine disorders or to a positive family history of IDDM, the duration of symptoms before diagnosis, preceding infections and the degree of metabolic derangement at diagnosis nor did ICA. Patients positive for IF-ICA had higher titers of IAA (5.5 ± 0.9 vs. 2.5 ± 0.3 (±SEM);p<0.01) at diagnosis. Coxsackie-B4- or mumps-virus specific IgG–, IgM- or IgA-nntibodies had no association to IAA and/or ICA at diagnosis. However, subjects with recent mumps infection (n=13) had higher IAA levels compared to the 181 subjects without(p<0.02). In conclusion this study substantiates on one fiand the association between IAA and IF-ICA and dissociation between autoantibodies (IAA and ICA) and Coxsackie-B4- and mumps-virus specific antibodies on the other. However, the relationship between recent infection and autoantibodies remains to be confirmed.
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Karjalainen, J., Knip, M., Hyoty, H. et al. RELATION BETWEEN INSULIN AUTOANTBODIES (IAA), ISLET CELL ANTIBODIES (ICA) AND COXSACKIE-B4− AND MMPS-VIRUS SPECIFIC ANTIBODIES AT DIAGNOSIS OF INSULIN-DEPENDENT DIABETES MELLITUS (IDDM). Pediatr Res 23, 136 (1988). https://doi.org/10.1203/00006450-198801000-00208
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DOI: https://doi.org/10.1203/00006450-198801000-00208